This ‘inflamed’ immune profile was similar to CMS4 subtype of CRC that is characterized by marked up-regulation of immune suppressive factors, such as Transforming Growth Factor Receptor beta (TGFβ) and Chemokine (C-X-C motif)12 (CXCL12), and high expression of genes encoding chemokines that attract myeloid cells, including C-C motif chemokine ligand 2 (CCL2) and the related cytokines IL-23 and IL-17 [14–17]. The gene discussed is CXCL12; the disease is colorectal carcinoma.