PD-L1 positivity in that trial was determined using the Ventana PD-L1 [SP142] immunohistochemical assay (Roche Diagnostics USA) and was defined based on the percentage of PD-L1–expressing immune cells as a percentage of tumor area: IC3 (≥ 10%), IC2 (≥ 5% to < 10%), IC1 (≥ 1% and < 5%), and IC0 (< 1%). Here, CD274 is linked to neoplasm.