Decreased PCNA, MMP2, MMP9, Vimentin, Catenin beta and N-cadherin, increased E-cadherin and Cytokeratin7, and decreased activities of Wnt/Catenin beta and MEK/ERK pathways could be detected in miR-338-3p overexpression lentivectors transfected xenograft tumor tissues. The gene discussed is MMP9; the disease is neoplasm.