Taken together, using database query and in vivo and in vitro assay, our study showed restoration of miR-338-3p could suppress the growth and metastasis of ovarian cancer cells in vitro and in vivo, which was implicated in MACC1 and Met regulated Wnt/Catenin beta and MEK/ERK pathways. This evidence concerns the gene MAPK1 and ovarian carcinoma.