In present study, we overexpressed miR-338-3p, MACC1, one 3′-untranslated regions (UTRs) binding target gene of miR-338-3p, and its regulated gene MET in ovarian cancer cells respectively to explore the effects on proliferation, epithelial to mesenchymal transition (EMT) and downstream pathways in vitro and in vivo, and to elaborate the roles of miR-338-3p in the growth and metastasis of ovarian cancer. The gene discussed is MET; the disease is ovarian carcinoma.