Upregulations of miR-338-3p, E-cadherin and Cytokeratin7, downregulations of MACC1, Met, PCNA, MMP2, MMP9, N-cadherin, Vimentin, Catenin beta, p-MEK1/2, p-ERK1/2, Wnt3a and p-LRP6 were detected respectively in miR-338-3p restoration cells injected mice tumor tissues compared to control cells injected mice tumor tissues (Fig. 8a-e). Here, MAPK3 is linked to neoplasm.