In-patients with MMA/PA, the appearance of metabolic acidosis (MMA: 13.14%, PA: 19.14%) and anemia (MMA: 19.23%, PA: 15.61%) were relatively common, followed by elevated ALT/AST/LDH, low PLT, elevated NH3, hypoglycemia, low WBC, decreased eGFR and elevated uric acid. The gene discussed is GPT; the disease is metabolic acidosis.