Our data showed that the serum levels of PMN elastase and ENR were higher in the anti-PM-Scl positive group than in the anti-PM-Scl negative group (5022.2 (2259.9–6684.8) vs 1445.8 (738.3–3404.8), ng/mL, P = 0.007, and 1127.4 (866.8–2224.2) vs 317.5 (146.4–692.6), P < 0.001) in patients with IIMs, which was also observed in patients with DM. The gene discussed is EXOSC10; the disease is dermatomyositis.