ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Taking into account adipose inflammation is a hallmark of obesity, it is intriguing to speculate that attenuation of adipocyte-mediated HDL-lipidation and assembly by elevated levels of pro-inflammatory adipokines or reduced levels of anti-inflammatory adipokine adiponectin may directly contribute to lower plasma HDL-C levels in the state of obesity.