Comprehensive analyses of LncRNAs in CF tissues have identified two read through non-coding transcripts, EEF1E1-BLOC1S5 and ARHGAP19-SLIT1, an antisense LncRNA RN7SKP237, and 3 ultra-conserved LncRNAs, uc.363+, uc.8- and uc.476, that are significantly up- or down-regulated in the CF airway tissues. Here, BLOC1S5 is linked to cystic fibrosis.