Further experimentation should be conducted to elucidate whether the augmented levels of ALDH7A1, already reported to be a marker of advanced PCa [52, 53], can be supported by these metabolic alterations and eventually represent an adaptation mechanism resulting in higher levels of indoleacetic acid, thus supporting its correlation with PSA and lymph node progression. The gene discussed is ALDH7A1; the disease is posterior cortical atrophy.