GJA8 and early-onset non-syndromic cataract: In summary, we performed genetic analysis in five Chinese families with congenital dominant cataracts and identified five novel mutations, including an insertion mutation encoding p.S385Efs*83 in GJA3 and four missense mutations: p.F52 L in GJA8, p.G602R in BFSP1, p.T511 M in EPHA2 and p.R119H in HSF4. This work extended the mutation spectrum of congenital cataracts, and would provide more evidences for the precise diagnosis of the disease.