GH1 and short stature due to growth hormone qualitative anomaly: Such syndromes can be divided into two sugroups: those with normal sensitivity to GH [NSD, bio-inactive GH (Kowarski syndrome) or GHSR mutation] and those with low or absent sensitivity to GH (GH resistance, such as in children with mutations of GHR, IGFALS, STAT5B, STAT3 and IGF1)(50).