Gene enrichment analysis in terms of Jensen DISEASES revealed that genes with germline variants (PLXNA2, FAT2, and SYNE1) enriched in the Maltese breed are also enriched in several cancers, such as endometrial cancer (p < 0.01), pancreatic cancer (p < 0.05), and breast cancer (p < 0.05) (Figure 6C, Table S15). Here, SYNE1 is linked to familial pancreatic carcinoma.