The data presented suggest that the specific C16: 0-Cer ceramide produced by CerS6 plays an important role in the development of hepatic insulin resistance, therefore it can be assumed that the inhibition of CerS6-mediated ceramide C16: 0-Cer synthesis may be a potentially attractive target in the treatment of insulin resistance in obesity and T2D. Here, CERS6 is linked to Insulin resistance.