Moreover, we have demonstrated, that in females, glycemic parameters such as fasting glucose concentration, glucose concentration at 120 min in OGTT, and HbAc1, significantly correlated with those ceramide, which elevation was the highest in T2D patients, whereas in males, only C22:0-Cer significantly correlated with all the glycemic parameters. Here, ADCY8 is linked to type 2 diabetes mellitus.