LDLR and atherosclerosis: To test the effect of BPA on lipid metabolism and its role in developing atherosclerosis, eight-week old LDLR−/− mice were fed a high-fat diet and treated with 50 μg BPA/kg body weight, by gavage, as illustrated in the scheme in Figure 1A. We analyzed the pro-atherogenic effects of BPA in males as well as in females LDLR−/− mice because in females BPA may act also as an endocrine disrupter and may aggravate atherogenesis [36,37,38,39,40].