Several prognostic markers such as Rai and Binet staging systems, immunoglobulin VH gene mutational status [6], ζ-associated protein 70 (ZAP70) expression [7,8], cytogenetic abnormalities [9], and gene mutations can be used to predict the survival outcome and the need for treatment of patients with CLL [10,11]. Here, ZAP70 is linked to B-cell chronic lymphocytic leukemia.