On the other hand, it has been reported that IKKβ-deficient mice [36] and intra-articular gene transfer of the dominant negative form of IKKβ [35] inhibitors, such as NBD peptide, TAT-IκBα -super repressor, and IKKβ inhibitor, etc., [37,38,39,40,41] targeting the classical NF-κB pathway suppressed bone destruction in arthritis models. Here, NFKB1 is linked to arthritic joint disease.