Truncating mutations in the gene encoding the sarcomeric protein titin (TTN), frequently found in DCM patients [35], were associated with increased risk of ventricular arrhythmias, decreased cardiac mass as well as significant transcriptional upregulation of all components of the mitochondrial oxidative phosphorylation (OXPHOS) system [36]. The gene discussed is TTN; the disease is Ventricular arrhythmia.