The pro-inflammatory signaling is indicated by the upregulation of PRKRA and WDFY, which participate in the activation of NF-κB [81,82], a transcription factor and key regulator of immune and other functions, as well as a decreased abundance of SERPINA1E (an acute phase protein), which can attenuate microglia-mediated retinal degeneration [83]. This evidence concerns the gene PRKRA and retinal degeneration.