Napabucasin, which inhibits STAT3-mediated transcription of target genes that regulate stemness, such as Nanog, is in phase III trial for patients with metastatic colorectal cancer in combination with the trichemotherapeutic, FOLFIRI (NCT03522649), and metastatic pancreatic adenocarcinoma in combination with nab-paclitaxel and gemcitabine (NCT02993731), along with several other phase I studies in other cancers, with positive patient outcomes being associated with safety and tolerance already reported in several solid tumor types [214,215,216]. This evidence concerns the gene STAT3 and cancer.