While the dysregulation of several microRNAs (miRs), such as let-7 [104] and miR-629 [105], might induce oncogenic transformation of epithelial cells through reciprocal STAT3 signaling, STAT3-driven tumor development largely results from loss of competent immune signaling and the induction of inflammatory responses in the TME [103]. Here, STAT3 is linked to neoplasm.