Conversely, the anchoring of JAK2 in the nucleus has been linked to gene expression disruptions through direct phosphorylation of histones, such as H3Y41, which displaces the binding of heterochromatin protein 1α (HP1α) [144] to promote the loss of HP1α-mediated tumor and metastasis suppressive functions that occur through the regulation of genes that are associated with cell mitosis and adhesion [145,146]. The gene discussed is JAK2; the disease is neoplasm.