The genetic risk variants were then categorized into three groups, based on their pattern of association with glioma molecular subgroups: (1) SNVs in TP53 and TERT associated with all glioma; (2) SNVs in CDKN2B-AS1, EGFR, near EGFR, and RTEL1 associated with IDH-wt glioma; and (3) SNVs in CCDC26, C2orf80, PHLDB1, ETFA, LRIG1, ZBTB16 and MAML2 associated with IDH-mutant glioma. Here, TP53 is linked to central nervous system cancer.