However, it was also shown that a loss of TGFBR1 expression correlates with poor prognoses of bladder cancer patients [182] while loss of TGFBR1 and TGFBR2 correlated with increased bladder tumor grades [183], which agrees with the decreased TGFBR2 expression in invasive tumors compared with superficial transitional cell carcinomas [184]. Here, TGFBR2 is linked to urinary bladder neoplasm.