There, a loss of TGF-β1 receptors, TGFBR1 and TGFBR2, correlated with the invasive tumor stage, high grade, and lymphovascular invasion while enhanced TGF-β1 levels in bladder cancer tissues and plasma of patients were associated with tumor invasiveness [121,122]. This evidence concerns the gene TGFBR1 and urinary bladder cancer.