miR-15a/16 target and downregulate expressions of SMAD3 and ACVR2A, resulting in attenuated expression of TGF-β dependent genes, including MMP2, E-cadherin, Snail, and Twist, and leading to inhibition of EMT and invasion of prostate cancer cells [304]. The gene discussed is TGFB1; the disease is Familial prostate cancer.