Furthermore, Ananth et al. demonstrated inactivation of TGF-β signaling in a 786-0 ccRCC-derived cell line due to the loss of the TGRBR2 receptor, whereas Sjolund et al. provided evidence that this pathway is functional in the same cell line [139,146]. This evidence concerns the gene TGFB1 and nonpapillary renal cell carcinoma.