In addition to the alleviation of the adhesive and migratory abilities, melatonin induces apoptosis in SOSP-9607 cells via the down-regulation of sirtuin 1 (SIRT1, a conserved nicotinamide adenine dinucleotide-dependent deacetylase), which has an association with age and cancer [68], thus leading to increased p53 acetylation. This evidence concerns the gene SIRT1 and cancer.