Furthermore, a recent study suggested that DDB1 and Cullin-RING ubiquitin ligases (CRL) 4, the ubiquitin ligase of Cullin 4A (CUL4A)-DDB1 E3, are important factors in ovarian cancer chemoresistance because they regulate apoptosis and might be therapeutic targets for patients after cisplatin failure [15]. The gene discussed is CUL4A; the disease is ovarian cancer.