The trend of lower expression of PMEPA1-b and higher expression of PMEPA1-a was perspicuous in the subgroup with the highest Gleason score (Gleason 8 to 10), suggesting the divergent roles played by PMEPA1-a and b via different signaling pathways in late-stage prostate cancer. This evidence concerns the gene PMEPA1 and Familial prostate cancer.