TGFB1 and Familial prostate cancer: Moreover, the significant reverse correlations between PMEPA1-a and TGF-β responsive genes such as THBS1 (p = 0.0001, R = −0.37837) and NEDD9 (p = 0.0275, R = −0.22506) in tumor tissue were detected, further substantiating the inhibition effects of PMEPA1-a on TGF-β signaling in prostate cancer cells (Figure 4I).