TDP‐43 proteinopathy is a pathological hallmark of ALS with cytoplasmic misaccumulation of TDP‐43 found in MNs and glial cells (Arai et al., 2006; Ling, Polymenidou, & Cleveland, 2013; Neumann et al., 2006). Here, TARDBP is linked to amyotrophic lateral sclerosis.