Although TDP‐43 proteinopathies are the pathological hallmark of ALS regardless of patients' genotypes, with TDP‐43 deposition observed in astrocytes in post‐mortem tissues (Yamanaka & Komine, 2018) no post‐mortem studies have yet reported TDP‐43 proteinopathies in astrocytes in C9orf72‐related ALS. This evidence concerns the gene C9orf72 and proteostasis deficiencies.