APOBEC3B and cancer: These specific associations between germline sequence in the APOBEC3B region and modulation of the APOBEC mutation signature in cancers provide evidence for its potential as a cancer mutator and are validated by experimental evidence indicating that reduction of A3B can be anti-mutagenic [22] and recent determination that endogenous A3B is responsible for induced kataegis events in RPE-1 cells [59].