SOD1 and nervous system disorder: But under stress conditions, Nrf2 detaches from Keap1 and translocates to the nucleus, and counteracts the promotion of ROS production through transcriptional increase of antioxidant proteins, including SOD, CAT, HO1, NQO1, GCLM and GCLC, which subsequently modulate oxidative stress, apoptosis and inflammation in diverse neurological disorders [45, 46].