RRN3 and infection: As depleting TIF-IA had no detectable impact on IFNB1 mRNA accumulation in response to infection with the RNA virus vesicular stomatitis virus (VSV), this suggested that rRNA biogenesis selectively influenced IFNB1 induction in response to viruses like HCMV with dsDNA genomes (Figure 4F) (Yanai et al., 2009).