By contrast, HMGB2-depletion had no detectable impact on IFNB1 accumulation induced in response to infection with VSV, an RNA virus (Figure 7D), in agreement with reports showing HMGB2 was dispensable for IFNB1 induction by RNA in murine cells (Yanai et al., 2009). The gene discussed is HMGB2; the disease is infection.