IRF3 and Diamond-Blackfan anemia: Formation of a multipartite complex including STING and S6K is needed to activate IRF3 in response to DNA sensing (Wang et al., 2016) A ribosomal protein deficiency resulting in Diamond-Blackfan Anemia (DBA) impairs rRNA processing and ribosome biogenesis, resulting in activation of innate immune signaling (Danilova et al., 2018).