Compared with this meta-analysis, our meta-analysis focused on overall autoimmune diseases risk and showed that FAS −670 A/G polymorphism was associated with autoimmune diseases risk in Caucasians, MS, SSc and HT; and the FAS −1377 G/A polymorphism was associated with autoimmune diseases risk in Asians and high quality studies, which were different from the previous meta-analyses. This evidence concerns the gene FAS and autoimmune disease.