On the basis of ethnicity, the stratified meta-analysis showed an association between FAS −670 A/G polymorphism and the risk of autoimmune diseases in Caucasians (GG vs. GA: OR = 1.12, 95% CI 1.03–1.23, P=0.012) and Asians (G vs. A: OR = 0.89, 95% CI 0.83–0.96, P=0.002) but not in other ethnic groups. Here, FAS is linked to autoimmune disease.