In the FAS −1377 G/A polymorphism, our results indicated that FAS −1377 G/A polymorphism was associated with the risk of autoimmune diseases (A vs. G: OR = 1.11, 95% CI = 1.03–1.20, P=0.008; AA vs. GG: OR = 1.23, 95% CI = 1.03–1.47, P=0.024; AA+AG vs. GG: OR = 1.14, 95% CI = 1.02–1.26, P=0.015). The gene discussed is FAS; the disease is autoimmune disease.