To our knowledge, this is the most comprehensive meta-analysis to assess the association of an FAS polymorphisms with the risk of autoimmune diseases, including SLE, RA, MS, AIH, LN, SSc, AA, pSS, HT, GBS, PBC, vitiligo, GD, T1D, IAA, JIA, and SPA. Here, FAS is linked to primary biliary cholangitis.