Thus, in the present study, we aimed to perform a meta-analysis to investigate whether the FAS −670 A/G or −1377 G/A polymorphisms is associated with autoimmune diseases risk by including 23 new articles, consisting of 33 studies [15,17,22,27–30,32–35,37,41,43–45,50,52–55,59,60] on SLE, MS, pSS, AA, PBC, HT, GBS, LN, vitiligo, T1D, IAA, and GD and correcting the errors in the previous meta-analyses. This evidence concerns the gene FAS and lobular neoplasia.