On the basis of disease type, the stratified meta-analysis suggested that the FAS −670 A/G polymorphism might be associated with the risk of SLE (G vs. A: OR = 0.85, 95% CI 0.77–0.94, P=0.001), MS (GG+GA vs. AA: OR = 0.83, 95% CI 0.70–0.99, P=0.043), SSc (GG vs. GA: OR = 1.20, 95% CI 1.07–1.36, P=0.003), and HT (G vs. A: OR = 1.45, 95% CI 1.10–1.90, P=0.008). This evidence concerns the gene FAS and systemic sclerosis.