To our knowledge, this is the most comprehensive meta-analysis to assess the association of an FAS polymorphisms with the risk of autoimmune diseases, including SLE, RA, MS, AIH, LN, SSc, AA, pSS, HT, GBS, PBC, vitiligo, GD, T1D, IAA, JIA, and SPA. The gene discussed is FAS; the disease is systemic sclerosis.