One previous meta-analysis [62] including SLE, RA, SSc, pSS, JIA, and SPA demonstrated that the FAS −670 A/G polymorphism might be associated with the risk of rheumatic disease, especially in Asians, SLE and RA, and the FAS −1377 G/A polymorphism was associated with SLE risk. This evidence concerns the gene FAS and systemic sclerosis.