Released lactate is then taken up by tumor‐associated macrophages via MCT1, promoting in turn macrophage polarization toward a TAM (M2) phenotype with high expression of arginase 1 (Arg1), vascular endothelial growth factor (VEGF) production and subsequently tumor growth (Colegio et al., 2014; Figure 2). Here, VEGFA is linked to neoplasm.