IFNG and cancer: Upon phosphorylation of Ser-727, STAT1 dimerizes and its homodimers translocate to the nucleus, localize to target gene promoters inducing transcription.20 IFN-γ has been recognized as a key player in anti-tumor immune responses.21 The cytokine induces cancer cell apoptosis and growth arrest22–24 and its secretion by activated CD8 cytotoxic T cells in the tumor milieu is responsible for T cell-induced anti-tumor effects.