IFNB1 and neoplasm: Among the key target genes, the inflammatory chemokines encoded by CXCL10 (C-X-C motif chemokine 10) and CXCL11 (C-X-C motif chemokine 11) promote T cell chemotaxis and play a role in anti-tumor immunity.28IFI16 (interferon gamma inducible protein 16) is an innate sensor for intracellular DNA that triggers a pro-inflammatory and growth inhibitory response through activation of IFN-β and NF-κB pathways.29–31 Basal levels of CXCL10 (~20-fold), CXCL11 (~15-fold), and IFI16 (~160-fold) were significantly upregulated in BRCA1-null (+vector) vs. BRCA1+ OC cells (Fig. 3a).