BRCA1 and ovarian serous adenocarcinoma: The most commonly mutated TSG associated with hereditary OC, BRCA1, has been implicated in the initiation of events leading to transformation of the ovarian/fallopian tube epithelium.4,5 Inactivating BRCA1 mutations occur in approximately 5–10% of all high-grade serous ovarian cancers (HGSOC) and account for more than half of the inherited syndromes associated with OC.6 Additionally, epigenetic silencing of BRCA1 through promoter CpG island methylation occurs in approximately 20% of HGSOC,1,7 and has been linked to OC progression.