BRCA1 and ovarian neoplasm: Additionally, 1117 genes were differentially expressed both in BRCA1-null vs. BRCA1+ OC cells and in the BRCA1-deficient vs. BRCA1-normal ovarian tumors (Fig. 2c), supporting similarity between the selected cellular model to study BRCA1 mutation-associated transcriptomic changes and human HGSOC tumors.