These analyses integrated with gene expression profiles of BRCA1-deficient (mutated BRCA1 or expression levels below the tenth quantile) or BRCA1-normal (not mutated BRCA1 and expression level above the first quartile) HGSOC tumors profiled in The Cancer Genome Atlas (TCGA) project1 pointed to an IFN-γ signature being hyper-active at baseline in BRCA1-mutated cancer cells. Here, BRCA1 is linked to cancer.