NRP1 and neoplasm: In addition, disruption of VEGF-NRP1 axis inhibits the tumor cell autocrine signaling via regulating the expression and function of various downstream effector molecules including Ras and β-catenin.16,18 Therefore, it is not at all surprising that EG00229 demonstrates combined antiangiogenic and antitumor activity to delay tumor progression in multiple cancer models.18,36,37 Moreover, the immune-modulatory function of EG00229 has been suggested in a recent article.39