Consistent with this result, Sp1 expression was markedly increased in the hippocampus (457.51 ± 112.89%, p = 0.025; Fig. 2m) and temporal cortex (190.51 ± 33.85%, p = 0.033; Fig. 2n) of AD patients (n = 6) relative to controls (n = 4). The gene discussed is SP1; the disease is Alzheimer disease.