MAPK8 and Alzheimer disease: Dysregulation of MKP-1 might disrupt neuronal development and cognitive function.35 A recent study has shown that MKP-1 exerts a neuroprotective role in Aβ-induced apoptosis, neuroinflammation, and oxidative stress by inactivating JNK.36 However, the exact role of MKP-1 in AD pathogenesis remains largely unclear.