In contrast, knockdown of MKP-1 by AAVshMKP-1 increased the levels of Aβ40 (AD + AAVshMKP-1: 539.84 ± 88.00 pg/mg) (p < 0.001; Fig. 5f) and Aβ42 (AD + AAVshMKP-1: 425.10 ± 53.85 pg/mg) (p = 0.003; Fig. 5g). The gene discussed is DUSP1; the disease is Alzheimer disease.