However, upregulation of MKP-1 by AAVMKP-1 markedly shortened the escape latency (p = 0.016; Fig. 6a), whereas downregulation of MKP-1 by AAVshMKP-1 increased the escape latency in the AD mice (p = 0.006; Fig. 6a). This evidence concerns the gene DUSP1 and Alzheimer disease.