Compared to the alcohol-treated WT mice, mice with genetic ablation of NR4A1 exhibited attenuation of hepatocyte vacuolation (Fig. 7m, n), fibrosis (Fig. 7n, o), steatosis (Fig. 7n, p), and caspase-9-related mitochondrial apoptosis (Fig. 7q) induced by alcohol treatment. The gene discussed is CASP9; the disease is steatosis.