DKK1 is well established as a key regulator of the Wnt/β-catenin signaling pathway.7 Increased expression of DKK1 is associated with cytoplasmic/nuclear β-catenin accumulation in HCC patients.20 Therefore, we investigated whether DKK1 can activate the Wnt/β-catenin signaling pathway. This evidence concerns the gene DKK1 and hepatocellular carcinoma.