DKK1 and hepatocellular carcinoma: β-Catenin is the key functional protein in the Wnt/β-catenin signaling pathway.26,32 It has been reported that β-catenin translocates from the cytoplasm to the nucleus and is essential for tumorigenesis.33,34 However, whether DKK1 is involved in the regulation of β-catenin in HCC cells is unclear.