The earliest Gail Model took into account of age at menarche, age at the time of first live birth, the number of first degree relatives with breast cancer, the number of breast biopsies; later, history of breast cancer, ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS), BRCA1/2 mutation status, current age, biopsy displaying atypical hyperplasia and race were added into the model. The gene discussed is BRCA1; the disease is breast cancer.