PC4 silenced cells migrated faster as compared to control (scramble siRNA) in both HBL-100 and MCF7cells (Supplementary Figure 2B).Breast cancer cell lines MDA-MB-231 and MCF7 were also subjected to Boyden chamber invasion assay upon transient PC4 silencing (Figure 2D and Supplementary Figure 2A). This evidence concerns the gene SUB1 and breast cancer.