When compared to advanced but localized prostate tumors in B6 Hi-Myc mice (Figure 1), B6CaP allografts maintained a similar phenotype of luminal cytokeratin expression (CK8), strong androgen receptor (AR) expression, and high levels of MYC expression from the Hi-Myc transgene [10] (Figure 1A–1H). Here, AR is linked to prostate neoplasm.