CCL18 is mainly expressed and spontaneously secreted by cancer cells and stoma cells including monocytes, macrophages and immature dendritic cells etc. CCL18 secreted from M2-type TAMs is increased not only in chronic inflammations 24, fibrotic diseases 25, 26 and white adipose tissue dysfunction 27, but also in various types of neoplastic diseases. This evidence concerns the gene CCL18 and neoplasm.