Later on, the same group demonstrated that miR-34a and miR-34c, which are downregulated in NSCLC cell lines, could play a significant role in lung carcinogenesis by modulating the expression of PDGFR-α/β(platelet derived growth factor receptor-α/β) and thereby regulating TRAIL-induced cell death sensitivity 86. This evidence concerns the gene TNFSF10 and non-small cell lung carcinoma.