cAMP can regulate LKB1 through cAMP-responsive element-binding protein (CREB) to affect the LncRNA LNC00473's activity, and then play an vital role in multi-drug resistance of lung cancer patients 85, given that overexpressed LINC00473 is correlated with poor prognosis, and stabilized expression of LINC00473 was required for cell proliferation and cell survival in LKB1-inactivated NSCLC cells. This evidence concerns the gene PDE10A and lung cancer.