NR4A1 and acute myeloid leukemia: Furthermore, the deletion of NR4A1 and NR4A3 in mice is found to lead to AML13, and redujinction in the gene dosages of NR4A1 and NR4A3 in hypoallelic mice beyond a critical threshold is sufficient to cause mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), along with AML progression14.