Luisa et al. found that HMGB1 translocated from nuclei to cytoplasm and observed a positive relationship between HMGB1 and eosinophil scores after stimulating with lipopolysaccharide (LPS) in human nasal epithelial cells, suggesting that HMGB1 plays an important role in ECRSwNP 17, but the mechanism of the relationship between HMGB1 and formation of nasal polyp in ECRSwNP is unclear. This evidence concerns the gene HMGB1 and nasal cavity polyp.