In addition, this finding was specific on ECRSwNP, which demonstrate the effect of HMGB1 on pathogenesis of ECRSwNP, but was not differentiated into ECRSwNP, non-ECRSwNP, CRSsNP and normal tissues, which may illustrate the difference of HMGB1 in the pathogenesis of chronic inflammatory disease in the nasal cavity. The gene discussed is HMGB1; the disease is chronic rhinosinusitis without nasal polyps.