Analysis of a national dataset find a significantly increased risk of osteoporosis among general population with hypoalbuminemia; with albumin <3.5g/dL patients has 5.37 fold at femoral neck, 12.46 fold at total femur, and 4.59 fold at lumbar spine higher risk of osteoporosis as compared to those with albumin >4 mg/dL 52. The gene discussed is ALB; the disease is Hypoalbuminemia.