BRAF and melanoma: ETV4 is a member of the polyomavirus enhancer activator 3 (PEA3) subfamily of the Ets transcription factor family and regulates genes that promote metastasis.38 As well as inducing ETV4 expression, ERK1/2 promotes ETV4 activation by phosphorylation and sumoylation.34,39,40 Previous studies reported inconsistent findings regarding the contribution of ETV4 to cell survival.41,42 Our data indicate that ETV4 depletion inhibited cell survival of BRAF wild-type melanoma cells but did not influence response to MEK inhibition.