MAP2K7 and cancer: Mutation status was determined for 64 of the 83 patients randomised in the DOC-MEK study, in 59 cases by NGS using targeted sequencing of 46 cancer-associated genes (Fig. 1a, Supplementary Table 1) and in five cases (DM005, DM026, DM029, DM037 and DM083) using pyrosequencing.