Several reports suggest that this glycoprotein is involved in cell renewal and proliferation.23–25 While overexpressed in some types of cancers, including prostate, bladder, and pancreatic cancer,23,26,27 it is downregulated in esophageal and gastric cancer.28 Functional analysis in a previous GWAS revealed a considerable function for PSCA rs2294008. This evidence concerns the gene PSCA and gastric cancer.