Moreover, we conducted flow cytometry with antibodies against IFN-γ and CD8 in these positive samples, and found that the frequency of IFN-γ + and CD8 + TILs among the TILs co-cultured with the autologous tumor cell lines was significantly higher than that in the TILs alone, while the expression of SRSF2 in these TILs was downregulated by siSRSF2 (Fig. 1c–i). The gene discussed is SRSF2; the disease is neoplasm.