Given that the H3K27Ac level near the TSS of genes influences the binding ability of STAT3, an important transcriptional factor for gene expression [36], to target genes [37, 38], and that STAT3 plays vital roles in inducing tumor immune tolerance [39], we hypothesized that STAT3 is involved in SRSF2-mediated gene expression immune checkpoints. This evidence concerns the gene STAT3 and neoplasm.