PRDX2 and cancer: Accordingly, Prdx2 knockout mice developed hemolytic anemia and Heinz body formation already at 5 weeks, while Prdx1 knockout mice showed the onset of malignant tumor and Heinz body hemolytic anemia only after 9 months of age; no erythrocyte abnormalities were reported in mice genetically deleted for Prdx6 [19,44].