The non-receptor tyrosine phosphatase PTPN1 (also known as PTP1B) constitutes the paradigm of PTP enzymes and a suitable drug target for cancer and metabolic diseases [30–33], and PTPN1 protein expression has been shown to correlate with metastasis and poor prognosis in several human cancers [34–37]. This evidence concerns the gene PTPN1 and Other metabolic disease.