Thus, it could be hypothesized that oxidative and nitrosative stress—measured both by serum levels of MDA [8], the most studied biomarker of lipid oxidation end product, and NO [8, 29–31], a well-known oxidant/vasodilator with a pivotal role in migraine pathogenesis—may be present to a greater extent in migraine patients compared with the healthy population while, at the same time, lower antioxidant defense assessed by total non-enzymatic antioxidant capacity and the most-known antioxidant enzymes (CAT, SOD, GPx-1) [8] might also be detected in this population. This evidence concerns the gene GPX1 and migraine disorder.