To test whether miR-204 exerts beneficial effects on IRDs, we used a model for an autosomal-dominant (AD) IRD, namely, the transgenic RHO-P347S mouse, which carries a copy of the human RHODOPSIN(RHO) gene harboring the proline347-to-serine mutation.16 The gene discussed is RHO; the disease is respiratory distress syndrome in premature infants.